Antibacterial constituents from Uncaria tomentosa

نویسندگان

  • Graham White
  • Natalie Bourbonnais-Spear
  • Frank Garner
چکیده

traditionally used for treatment of several diseases including its theoretic use in microbial We have isolated three flavonoids (Artochamin C, 5'Hydroxycudraflavone A and Dihydrocudraflavone B) based on bioactivity guided isolation. All compounds showed significant antibacterial activities against Escherchia coli, Staphylococcus aureus, Klebsiella pneumoniae and Bacillus subtilis. Artochamin C (1) was the most active among all compounds with MIC values ranging from 4.1 μg/mL to 6.7 μg/mL. Other compounds also exhibited considerable antibacterial activities. Neomycin was used as a positive control. Preliminary results of isolated compounds have justified ethnopharmacological use of Uncaria tomentosa in microbial infections

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تاریخ انتشار 2011