Antibacterial constituents from Uncaria tomentosa
نویسندگان
چکیده
traditionally used for treatment of several diseases including its theoretic use in microbial We have isolated three flavonoids (Artochamin C, 5'Hydroxycudraflavone A and Dihydrocudraflavone B) based on bioactivity guided isolation. All compounds showed significant antibacterial activities against Escherchia coli, Staphylococcus aureus, Klebsiella pneumoniae and Bacillus subtilis. Artochamin C (1) was the most active among all compounds with MIC values ranging from 4.1 μg/mL to 6.7 μg/mL. Other compounds also exhibited considerable antibacterial activities. Neomycin was used as a positive control. Preliminary results of isolated compounds have justified ethnopharmacological use of Uncaria tomentosa in microbial infections
منابع مشابه
Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon eques
Uncaria tomentosa is a medicinal plant used in folk medicine by Amazon tribes. In this study the constituents of aqueous extract of U. tomentosa bark were quantified by chromatographic technique and its lethal concentration 50 (48 h) in Hyphessobrycon eques was determined. The chromatography showed high levels of oxindole alkaloids, quinovic acid glycosides, and low molecular weight polyphenols...
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